Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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Page 17 of about 221 results

ea0020p583 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Adiponectin and visfatin: a link with bone mineral density in acromegaly

Resmini Eugenia , Sucunza Nuria , Barahona M Jose , Santos Alicia , Fernandez-Real J Maria , Ricart Wilfredo , Moreno J Maria , Farrerons Jose , Espinosa Jose Rodriguez , Marin AM , Webb Susan M

Two adipokines highly expressed in fat mass, adiponectin with antiinflammatory and antiatherogenic properties, and visfatin with an insulin-mimetic effect, are potential contributors to bone metabolism. In acromegaly data on adiponectin are contradictory and there are no data on visfatin.Objectives: To evaluate adiponectin and visfatin in acromegaly, compared to control subjects and to analyze their relationship with body composition and bone mineral mar...
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ea0020p588 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Quality of life (QoL) in patients with Cushing's syndrome in a Spanish population: new experience with the CushingQoL questionnaire

Alicia Santos , Eugenia Resmini , Jose Barahona Ma , Camelia Marti , Cheryl Farkas , Olga Roig , Ma Antonia Martinez , Nuria Sucunza , Xavier Badia , Susan M Webb

Quality of life is impaired in patients who have suffered Cushing’s syndrome (CS).Aim: Evaluate QoL with the new questionnaire CushingQoL in Spanish patients in a clinical practice setting and compare it with a generic QoL questionnaire, EuroQoL-5 Dimensions (5D) and its Visual Analogue Scale (VAS).Patients and methods: Forty-three patients with CS (38 pituitary-dependent, 28 cured) were approached during their regular endocri...
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ea0016s24.4 | State of the art in the therapy of pituitary disease | ECE2008

Development of a disease-related QoL-questionnaire for Cushing’s disease

Webb Susan M , Badia Xavier , Barahona Maria-Jose , Colao Annamaria , Strasburger Christian J , Tabarin Antoine , van Aken Maarten , Pivonello Rosario , Stalla Gunther , Lamberts Steven W J , Glusman Joan

Chronic exposure to hypercortisolism significantly impacts on patient’s health and health-related quality of life (HRQoL). We developed a disease-generated questio-nnaire to evaluate HRQoL in Cushing’s syndrome (CS) (CushingQoL); in 125 (104 females) patients recruited in Spain, France, Germany, The Netherlands and Italy, clinical and hormonal data were collected and correlated with results of the generic SF-36 questionnaire, a question on self-perceived general heal...
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ea0015s13 | System-specific effect steroids | SFEBES2008

Glucocorticoid signalling in the brain

Lightman Stafford , Atkinson Helen , Droste Susanne-Katrin , Harbuz Michael , de Kloet Ronald , Linthorst Astrid , McKenna Mervyn , Reul Johannes , Seale Josephine , Wiles Crispin , Wood Susan , Conway-Campbell Becky

Aims: To define the ultradian pattern of corticosterone secretion in the rat, how this may be altered in different physiological states and the relevance of these patterns to nuclear signalling in the hippocampus.Methods: Rats were cannulated and attached to our automated blood sampling system. Some rats had simultaneous intracranial microdialysis for free corticosterone in the hippocampus and other rats were adrenalectomised and corticosterone replaced ...
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ea0014p533 | (1) | ECE2007

Effects of glucocorticoid replacement on bone mass in women after long-term remission of Cushing’s syndrome

Barahona Maria-Jose , Sucunza Nuria , Lluch Pilar , Fedrnandez-Real Jose-Manuel , Ricart Wifredo , Puig Teresa , Wäger Ana M , van Elzelingen Caroline , Farrerons Jordi , Webb Susan M

High dose and long-term glucocorticoid (GC) therapy reduce bone mass and negatively affect the metabolic profile. Patients in remission after successful treatment of Cushing’s syndrome (CS) often present hypoadrenalism and require long-term GC replacement.Objective: To evaluate the effect of GC therapy on bone and metabolic parameters in women after long-term remission of CS. Materials and methods: Thirty-two women (mean age: 50±14 years) with ...
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ea0056gp207 | Pituitary Clinical | ECE2018

Molecular profiling of non-functioning pituitary adenomas does not support pharmacological therapeutic options

Gil Joan , Blanco Alberto , Serra Guillermo , Salinas Isabel , Webb Susan M , Hostalot Cristina , Obiols Gabriel , Valassi Elena , Roig Olga , Sesmilo Gemma , Villabona Carles , Jorda Mireia , Puig-Domingo Manel

Non-functioning pituitary adenomas (NFPA) are the most common pituitary tumours. They usually come to medical attention because of a mass effect and/or hypopituitarism. Tumour shrinkage during therapy with either dopamine agonists (DA) or somatostatin analogues (SSA) has been previously reported in some cases; however, response of NFPA to medical treatment is still poor and unpredictable. Our aim was to explore the molecular mechanisms underlying this lack of efficacy through ...
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ea0095p84 | Adrenal 2 | BSPED2023

Evaluation of early morning cortisol levels compared to short synacthen test to assess adrenal function

Bornat Sylvie , Gorman Samantha , Hendriks Emile , Labeja Betty , Reyes Karis , Sparrow Susan , Thankamony Ajay , Marchovecchio Loredana , Oddy Sue , Walton-Betancourth Sandra

Background: The short synacthen test (SST) is commonly used to evaluate the integrity of the hypothalamic–pituitary–adrenal (HPA) axis in children. However, this test is time-consuming, requiring cannulation, several blood samples, and medical observation. Studies in adults have suggested an early morning serum cortisol level could be used to rule out or confirm adrenal insufficiency, reducing reliance on SSTs, however, few studies have evaluated thi...
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ea0098t1 | Trials In Progress | NANETS2023

ACTION-1: A randomized Phase Ib/3 trial of RYZ101 compared with SoC in SSTR+ well-differentiated GEP-NET with progression following Lu-177 SSA

Hope Thomas A. , Halperin Daniel , Strosberg Jonathan , Jacene Heather , E.T. Tesselaar Margot , Kunz Pamela L. , Ferreira Denis , Li Joanne , Ma Kimberly , Rearden Jessica , Moran Susan , Singh Simron

Background: Well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are commonly characterized by high-density expression of somatostatin receptors (SSTRs), which can be targeted by radiopharmaceutical therapy (RPT) via radiolabeled somatostatin analogues (SSAs). RYZ101 (225Ac-DOTATATE) is a first-in-class, highly potent alpha-emitting RPT being developed for the treatment of SSTR+ solid tumors. Alpha-particles (such as those emitted by 225<...
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ea0063cet1biog | Clinical Endocrinology Trust Lecture | ECE2019

Clinical Endocrinology Trust Award 2019 – Biography

Susan M. Webb was born and qualified from Medical School in Barcelona, Spain, and completed training at St. Bartholomew’s Hospital, London and in San Antonio, Texas. She is a Senior Consultant Endocrinologist at the Hospital Sant Pau, and Professor of Medicine at the Universitat Autònoma de Barcelona. She runs the Neuroendocrine Clinic and the Pituitary Disease network of excellence research group (CIBERER u...
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ea0013s2biog | Society for Endocrinology Transatlantic Medal Lecture | SFEBES2007

Society for Endocrinology Transatlantic Medal Lecture

Spiegelman B

B Spiegelman, Dana-Farber Cancer Institute, Boston, United States. AbstractA professor of Cell Biology at Dana-Farber and Harvard Medical School, Spiegelman earned his undergraduate degree with highest honours from the College of William and Mary in Williamsburg, Va., and his PhD in biochemistry from Princeton University. He completed his postdoctoral work at the Massachusetts Institute of Technology.<p class="abst...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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